ALK Breakapart

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Probe specification ALK, 2p23.2-p23.1, Red ALK, 2p23.2-p23.1, Green The ALK Breakapart probe consists of a green 420kb probe, which spans the majority of the ALK gene and a red 486kb probe, which is telomeric to the ALK gene. Probe information Transforming rearrangements of the Anaplastic Lymphoma Receptor Tyrosine Kinase (ALK) gene at 2p23 have been recognised in a subset of human haematological and solid malignancies1.

Product code : LPS 019

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Probe specification

ALK, 2p23.2-p23.1, Red

ALK, 2p23.2-p23.1, Green

The ALK Breakapart probe consists of a green 420kb probe, which spans the majority of the ALK gene and a red 486kb probe, which is telomeric to the ALK gene.

Probe information

Transforming rearrangements of the Anaplastic Lymphoma Receptor Tyrosine Kinase (ALK) gene at 2p23 have been recognised in a subset of human haematological and solid malignancies¹.

ALK fuses with Nucleophosmin (NPM1) in anaplastic lymphoma, resulting in constitutive kinase activity, which inhibits apoptosis and promotes cellular proliferation². The rearrangement of ALK has now also been implicated in the development of Non-Small Cell Lung Cancer (NSCLC) as a result of an inversion involving chromosome 2, inv(2)(p21p23), causing ALK to fuse with the EML4 gene². The ALK gene is frequently involved in translocations of chromosome 2 that lead to gene fusions in a variety of different malignancies, including neuroblastomas and myofibroblastic tumours³.