cMYC

Hematoloji problari

Probe specification cMYC, 8q24.21, Red cMYC, 8q24.21, Green The cMYC probe mix consists of a 173kb probe labelled in red, centromeric to the MYC gene that includes the marker D8S1153 and a 186kb probe, labelled in green telomeric to the MYC gene that includes the D8S1644 marker. Probe information Chromosomal rearrangements involving the MYC (MYC proto-oncogene, bHLH transcription factor) gene at 8q24 are recognised recurrent abnormalities commonly seen in patients with B-cell malignancy.

Product code : LPH 010

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Probe specification

cMYC, 8q24.21, Red

cMYC, 8q24.21, Green

The cMYC probe mix consists of a 173kb probe labelled in red, centromeric to the MYC gene that includes the marker D8S1153 and a 186kb probe, labelled in green telomeric to the MYC gene that includes the D8S1644 marker.

Probe information

Chromosomal rearrangements involving the MYC (MYC proto-oncogene, bHLH transcription factor) gene at 8q24 are recognised recurrent abnormalities commonly seen in patients with B-cell malignancy.

MYC rearrangements, activating MYC by translocation with one of the three immunoglobulin loci (IGH, IGL or IGK), are detected in almost all cases of Burkitt lymphoma at diagnosis¹. They are also seen in diffuse large B-cell lymphoma (DLBCL)², multiple myeloma and plasmablastic lymphomas^3,4, amongst other diseases.

MYC has also been shown on rare occasions to be involved in rearrangements with a number of non-immunoglobulin partners⁵.

The presence of concurrent MYC rearrangements with BCL2 and/or BCL6 rearrangements in patients with ‘dual-hit’ lymphoma has been shown to be associated with aggressive disease⁶.