EML4 Breakapart

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Probe specification EML4, 2p21, Red EML4, 2p21, Green The EML4 Breakapart probe consists of a green 406kb probe and a red 353kb probe, which are positioned on each side of the EML4 gene. Probe information The protein encoded by the echinoderm microtubule associated protein-like 4 (EML4) gene is involved in microtubule formation and stabilisation1.

Product code : LPS 020

Explanation
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Probe specification

EML4, 2p21, Red

EML4, 2p21, Green

The EML4 Breakapart probe consists of a green 406kb probe and a red 353kb probe, which are positioned on each side of the EML4 gene.

Probe information

The protein encoded by the echinoderm microtubule associated protein-like 4 (EML4) gene is involved in microtubule formation and stabilisation¹.

A novel gene fusion of EML4 and Anaplastic Lymphoma Kinase (ALK) was recently identified in Non-Small Cell Lung Cancer (NSCLC).

The EML4-ALK fusion was shown to result from an inversion within chromosome 2p, inv(2)(p21p23), and was detected in approximately 7% of NSCLC cases^2,3.