EWSR1 / ERG Translocation

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Probe specification EWSR1, 22q12, Red ERG, 21q22, Green The EWSR1/ERG Translocation probe consists of green probes (215kb, 154kb) flanking the breakpoint region at the ERG gene locus and red probes (139kb, 151kb) flanking the breakpoint region at the EWSR1 locus. Probe information Ewing's sarcoma (EWS) is the second most frequent primary bone cancer in patients under 20 years of age1. It is mainly characterised by a translocation between the two genes - EWSR1 (Ewing's Sarcoma Region 1) and FLI1 (Friend Leukaemia virus Integration 1) - in the t(11;22)(q24;q12) translocation, found in 83% of such tumours2. 10% of the remaining cases have a variant translocation involving EWSR1 and ERG, t(21;22)(q22;q12), and less than 1% carry one of the 7p22 (ETV1), 17q12 (E1AF) or 2q36 (FEV) translocations with EWSR13.

Product code : LPS 008

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Probe specification

EWSR1, 22q12, Red

ERG, 21q22, Green

The EWSR1/ERG Translocation probe consists of green probes (215kb, 154kb) flanking the breakpoint region at the ERG gene locus and red probes (139kb, 151kb) flanking the breakpoint region at the EWSR1 locus.

Probe information

Ewing's sarcoma (EWS) is the second most frequent primary bone cancer in patients under 20 years of age¹. It is mainly characterised by a translocation between the two genes - EWSR1 (Ewing's Sarcoma Region 1) and FLI1 (Friend Leukaemia virus Integration 1) - in the t(11;22)(q24;q12) translocation, found in 83% of such tumours². 10% of the remaining cases have a variant translocation involving EWSR1 and ERG, t(21;22)(q22;q12), and less than 1% carry one of the 7p22 (ETV1), 17q12 (E1AF) or 2q36 (FEV) translocations with EWSR13.

EWSR1 is also involved in translocations in desmoplasmic small round cell tumours, a subset of angiomatoid fibrous histocytomas, and possibly in myxoid liposarcoma^4,5.