IGH/CCND1 Translocation

Hematopatoloji problari

Probe specification IGH, 14q32.33, Green CCND1, 11q13.3, Red The IGH/CCND1 Plus product consists of probes, labelled in green, proximal to the Constant, and within the Variable segment of the IGH region and CCND1 probes, labelled in red. The CCND1 probe mix contains a 155kb probe centromeric to CCND1 gene, covering a region between the D11S2663 and the D11S4095 markers, and a second probe (162kb) covering the telomeric end of CCND1 gene and the region up to FGF3 gene. Probe information The t(11;14)(q13;q32) translocation involving CCND1 (cyclin D1) gene at 11q13.3 and the IGH (immunoglobulin heavy locus) gene at 14q32.33 is associated with mantle cell lymphoma.

Product code : LPH 072

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Probe specification

IGH, 14q32.33, Green

CCND1, 11q13.3, Red

The IGH/CCND1 Plus product consists of probes, labelled in green, proximal to the Constant, and within the Variable segment of the IGH region and CCND1 probes, labelled in red. The CCND1 probe mix contains a 155kb probe centromeric to CCND1 gene, covering a region between the D11S2663 and the D11S4095 markers, and a second probe (162kb) covering the telomeric end of CCND1 gene and the region up to FGF3 gene.

Probe information

The t(11;14)(q13;q32) translocation involving CCND1 (cyclin D1) gene at 11q13.3 and the IGH (immunoglobulin heavy locus) gene at 14q32.33 is associated with mantle cell lymphoma.

The t(11;14)(q13;q32) rearrangement involving CCND1 and IGH is considered the hallmark of mantle cell lymphoma (MCL)¹, the presence of which can be used to aid in the differential diagnosis of CD5+ B-cell lymphoproliferative disorders².