RET,10q11.21,Green
RET,10q11.21,Red
The RET Breakapart probe consists of two probes (92kb, 303kb), labelled in green, situated proximal to the RET gene and covering markers G17488 and D10S1100 and two probes (351kb, 112kb), labelled in red, situated distal to the RET gene and covering markers D10S1176 and D10S2221.
The RET (ret proto-oncogene) gene at 10q11 encodes for a transmembrane tyrosine kinase receptor involved in the control of cell differentiation, cell proliferation, and cell survival1.
Rearrangements involving the RET gene are recognised recurrent abnormalities seen in 1-2% patients with lung adenocarcinomas, where it is seen fused with KIF5B2,3, and papillary thyroid carcinoma where it is seen fused to a number of different partner genes including: CCDC6, PRKAR1A and NCOA44,5. The features of the proteins encoded by all types of RET fusion gene are similar to those of ALK: coiled-coil domains in the N-terminal fusion partners cause the RET domains to dimerize, resulting in activation of RET tyrosine kinase in the absence of ligands3.
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