ROS1 Plus, 6q22.1, Green
ROS1 Plus, 6q22.1, Red
The ROS1 Plus probe consists of 3 probes (175kb, 123kb, 171kb), labelled in green, situated proximal to the ROS1 gene and including markers D6S2428 and SHGC-149552 and a red probe (206kb) covering the distal part of the ROS1 gene and a region up to RH78348.
The ROS1 (ROS proto-oncogene 1, receptor tyrosine kinase) gene at 6q22 is an ALK (anaplastic lymphoma receptor tyrosine kinase) gene paralogue which encodes a type I integral membrane protein with tyrosine kinase activity1.
ROS1 rearrangements define a molecular subset of non-small cell lung cancer (NSCLC) and are seen in approximately 2% of patients with NSCLC2. A number of partner genes have been identified, including SLC34A2, CD74 and SDC43. It has been shown that these ROS1 fusions activate the pSTAT3, PI3K/AKT/mTOR and SHP-2 phosphatase pathways4,5.
NSCLC patients with ROS1 rearrangements have been shown to respond to treatment with ALK/MET tyrosine kinase inhibitors, such as crizotinib6.
ROS1 rearrangements with the GOPC (golgi associated PDZ and coiled-coil motif containing) gene fusion partner were originally reported in glioblastoma, but have now also been detected on cholangiocarcinoma, ovarian cancer and NSCLC patient samples7-9.
The ROS1 Plus design covers the ROS1 region and the region deleted in ROS1-GOPC fusions.
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