SRD (CHD5), 1p36.31, Red
1qter, 1q44, Green
The SRD (CHD5) Deletion probe consists of a 210kb red probe spanning the SRD (CHD5) gene region. The 1qter probe in green acts as a control for chromosome 1.
The 1p36 region is frequently deleted in a broad range of human cancers1. The Chromodomain Helicase DNA binding domain 5 (CHD5) gene acts as a tumour suppressor at 1p36.31 and is frequently deleted in human gliomas1, leukaemias/lymphomas2 and neuroblastomas3.
Deletion of the short arm of chromosome 1 is one of the most characteristic genetic changes in neuroblastoma, a tumour of the sympathetic nervous system. This is the most common childhood solid extracranial tumour, accounting for around 8%-10% of childhood cancers and 15% of childhood cancer deaths4.
The CHD5 gene has been characterised as the lead tumour suppressor candidate from the 1p36 smallest region of consistent deletion (SRD) region in neuroblastoma5.
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