TOP2A Amplification

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Probe specification TOP2A, 17q21.2, Red D17Z1, 17p11.1-q11.1, Green The TOP2A Amplification/Deletion probe consists of a red 164kb probe spanning the TOP2A gene region. The centromeric probe in green acts as a control for chromosome 17. Probe information The Topoisomerase 2A encoding (TOP2A) gene is located on chromosome band 17q21.2, near to the HER2 (ERBB2) oncogene. The TOP2A encoded protein has a function in DNA replication and the transcription of mRNA1,2. Amplification of the TOP2A gene is frequent in breast cancer and is often accompanied by HER2 amplification3.

Product code : LPS 002

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Probe specification

TOP2A, 17q21.2, Red

D17Z1, 17p11.1-q11.1, Green

The TOP2A Amplification/Deletion probe consists of a red 164kb probe spanning the TOP2A gene region. The centromeric probe in green acts as a control for chromosome 17.

Probe information

The Topoisomerase 2A encoding (TOP2A) gene is located on chromosome band 17q21.2, near to the HER2 (ERBB2) oncogene. The TOP2A encoded protein has a function in DNA replication and the transcription of mRNA^1,2. Amplification of the TOP2A gene is frequent in breast cancer and is often accompanied by HER2 amplification³.

TOP2A gene alterations are associated with an increased response to therapy using the anti-cancer drug anthracycline⁴, while patients with tumours that show normal levels of TOP2A and HER2 do not appear to gain any additional benefit from this drug⁴.