ZNF217 Amplification

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Probe specification ZNF217, 20q13.2, Red 20pter, 20p13, Green The ZNF217 Amplification probe consists of a 197kb red probe spanning the ZNF217 gene and neighbouring regions. The accompanying 20pter probe in green acts as a control for chromosome 20. Probe information The Zinc Finger protein 217 gene (ZNF217), which functions as a transcription repressor for a variety of genes1, is a strong oncogene candidate mapped within the 260kb minimum common amplicon at 20q13.22.

Product code : LPS 005

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Probe specification

ZNF217, 20q13.2, Red

20pter, 20p13, Green

The ZNF217 Amplification probe consists of a 197kb red probe spanning the ZNF217 gene and neighbouring regions. The accompanying 20pter probe in green acts as a control for chromosome 20.

Probe information

The Zinc Finger protein 217 gene (ZNF217), which functions as a transcription repressor for a variety of genes¹, is a strong oncogene candidate mapped within the 260kb minimum common amplicon at 20q13.2².

ZNF217 is amplified in breast cancer^2,3, ovarian cancer and other tumours^3,4,5 and is associated with aggressive tumour behaviour⁶. It has been shown that the silencing of ZNF217 inhibits ovarian cancer cell growth and their invasive ability in cancer cell lines⁷.